Characterization of a Multi-responsive Magnetic Graphene Oxide Nanocomposite Hydrogel and Its Application for DOX Delivery

Nanocomposite hydrogels are one of the most important types of biomaterials which can be used in many different applications such as drug delivery and tissue engineering.Incorporation of nanoparticles within a hydrogel matrix can provide unique characteristics like remote stimulate and improved mechanical strength.In this study,the synthesis of graphene oxide and graphene oxide nanocomposite hydrogel has been studied.Nanocomposite hydrogel was synthesized using carboxymethyl cellulose as a natural base,acrylic acid as a comonomer,graphene oxide as a filler,ammonium persulfate as an initiator,and iron nanoparticles as a crosslinking agent.The effect of reaction variables such as the iron nanoparticles,graphene oxide,ammonium persulfate,and acrylic acid were examined to achieve a hydrogel with maximum absorbency.Doxorubicin,an anti-cancer chemotherapy drug,was loaded into this hydrogel and its release behaviors were examined in the phosphate buffer solutions with different pH values.The structure of the graphene oxide and the optimized hydrogel were confirmed by Fourier-transform infrared spectroscopy,Raman spectroscopy,X-ray diffraction,scanning electron microscopy,and atomic force microscopy.     

Flow-driven Surface Instabilities of Tubular Chitosan Hydrogel

Spatial structures break their symmetry under the influence of shear stress arising from fluid flow. Here, we present surface instabilities appearing on chitosan tubes when an acidic solution of chitosan with various molecular weight is injected into a pool of sodium hydroxide solution. At slow flow rates wrinkle-to-fold transition takes place along the direction of the flow yielding a banded structure. For greater injection rates we observe coexisting modes of wrinkles and folds which are stabilized to periodic wrinkles when the alkaline concentration is increased. The instabilities are characterized by the scaling laws of the pattern wavelength and amplitude with the tube characteristics. Our experimental adaptation of mechanical instabilities provides a new in situ method to create soft biomaterials with the desired surface morphology without the use of any prefabricated templates.     

Fenugreek hydrogel–agarose composite entrapped gold nanoparticles for acetylcholinesterase based biosensor for carbamates detection

A biosensor was fabricated to detect pesticides in food samples. Acetylcholinesterase was immobilized in a novel fenugreek hydrogel–agarose matrix with gold nanoparticles. Transparent thin films with superior mechanical strength and stability were obtained with 2% fenugreek hydrogel and 2% agarose. Immobilization of acetylcholinesterase on the membrane resulted in high enzyme retention efficiency (92%) and a significantly prolonged shelf life of the enzyme (half-life, 55 days). Transmission electron microscopy revealed that, gold nanoparticles (10–20 nm in diameter) were uniformly dispersed in the fenugreek hydrogel–agarose–acetylcholinesterase membrane. This immobilized enzyme-gold nanoparticle dip-strip system detected various carbamates, including carbofuran, oxamyl, methomyl, and carbaryl, with limits of detection of 2, 21, 113, and 236 nM (S/N = 3), respectively. Furthermore, the fabricated biosensor exhibited good testing capabilities when used to detect carbamates added to various fruit and vegetable samples.     

温敏性纤维素/聚Ν-异丙基丙烯酰胺复合水凝胶的固体核磁共振表征及动力学研究

利用半互穿网络方法将具有温度响应的高分子聚N-异丙基丙烯酰胺( PNIPAM)与天然纤维素复合得到温敏性水凝胶。通过固体核磁共振的1 H,13 C CP/MAS(交叉极化/魔角旋转)和QCP(定量交叉极化)等实验手段对复合凝胶的结构进行了定性及定量研究,并利用固体静态变温核磁共振实验和偶极滤波-自旋扩散实验研究了复合凝胶中PNIPAM分子链段的动力学行为。     

Stability of shells of revolution made of a damageable nonlinear elastic material

The problem of bifurcation instability of shells of revolution made of a nonlinear elastic material progressively damaged under loading is formulated and solved __________ Translated from Prikladnaya Mekhanika, Vol. 43, No. 5, pp. 35–45, May 2007.     

弹性力学混合状态方程的小波解法

应用小波理论求解弹性力学混合状态方程，讨论了解的收敛性。从文中的数值算例不难看出，该方法不失为混合状态方程一种新的求解途径。     

弹性接触问题线性互补法的摄动原理

为使弹性摩擦问题的线性互补法得到收敛性保证,提出一个摄动原理,证明了通过“摆脱摄动误差”可得到原离散模型的精确解。     

各向异性弹塑性中厚度板壳的有限元分析

本文在文献［２，３］的基础上，提出了一个解各向异性弹塑性中厚度板壳问题的有限元方法。考虑材料各向异性的特点，采用了Ｈｉｌｌ推广的Ｈｕｂｅｒ－Ｍｉｓｅｓ屈服准则；借用Ｏｗｅｎ的剪切修正系数，正确计及了叠层复合材料壳体的横向剪切效应；为了避免“自锁”现象，文中采用了９节点的Ｈｅｔｅｒｏｓｉｓ二次壳单元；特别是本文利用插值外推的思想，提出了一个带预测的弧长增量控制法，显著提高了确定变形路径的计算效率。几个数值算例表明本文给出的有限元方法对于各向异性中厚度板壳的弹塑性分析有较好的精度，尤其是对具有复杂变形路径的结构计算，收敛速度提高更快。     

The elastic modulus of particulate composites using the concept of a mesophase

A theoretical model for the evaluation of the elastic modulus in particulate composites has been developed. The method takes into account the existence of a mesophase between main phases, which constitutes an important parameter influencing the behaviour of a composite material. This layer between the matrix and filler develops different physico-chemical properties from those of the constituent phases and variable ones along its thickness. The effect of the progressive variation of the elastic modulus of the mesophase on the modulus of the composite was estimated by applying various simple laws of variation. Convenient laws of variation were introduced, varying from a simple one, assuming a linear law, to a more refined one using a parabolic law. Experimental results with particulates, based on iron-filled epoxy composites, compared satisfactorily with other models. However, the model based on a parabolic law was superior to all others on physical grounds.List of symbols E elastic modulus - v Poisson's ratio - volume fraction - r radius - V volume - K bulk modulus - r thickness of mesophase - parameter which depends on the sudden changes of the heat capacity for the filled and unfilled polymer C _p ^f and C _p ⁰      

A centrally cracked thin circular disk, Part I: 3D Elastic–plastic finite element analysis

A full field solution, based on small deformation, three-dimensional elastic–plastic finite element analysis of the centrally cracked thin disk under mode I loading has been performed. The solution for the stresses under small-scale yielding and lo!cally fully plastic state has been compared with the HRR plane stress solution. At the outside of the 3D zone, within a distance of rσ_o/J=18, HRR dominance is maintained in the presence of a significant amount of compressive stress along the crack flanks. Ahead of this region, the HRR field overestimate the stresses. These results demonstrate a completely reversed state of stress in the near crack front compared to that in the plane strain case. The combined effect of geometry and finite thickness of the specimen on elastic–plastic crack tip stress field has been explored. To the best of our knowledge, such an attempt in the published literature has not been made yet. For the qualitative assessment of the results some of the field parameters have been compared to the available experimental results of K, gives a fair estimate of the crack opening stress near the crack front at a distance of order 10⁻² in. On the basis of this analysis, the Linear Elastic Fracture Mechanics approach has been adopted in analyzing the fatigue crack extension experiments performed in the disk (Part II).